In the year 2021, approximately 23.5 million individuals in the United States were diagnosed with an autoimmune disease, and the rates of prevalence are projected to rise. Additionally, there are over 80 distinct types of autoimmune disorders. Although numerous factors contribute to their onset, gaining a deeper understanding of these diseases can lead to better quality of life for those impacted.

What Constitutes an Autoimmune Disease?

An autoimmune condition arises when the immune system of the body erroneously targets its own tissues, mistaking them for intruders. This leads to an autoimmune response marked by the production of antibodies and is known as molecular mimicry.

Although the precise mechanisms remain unclear, it is believed that a mix of bacteria, viruses, and toxins contribute to the process. These elements could trigger inflammation within the body and initiate an autoimmune response, as evidenced by increased levels of antinuclear antibodies (ANA).

ANA refers to antibodies or proteins generated by the immune system to combat foreign substances or invaders. In contrast, antinuclear antibodies (ANA) target the body’s own healthy cells and tissues, which can result in damage to the body.

There are more than 80 recognized autoimmune disorders, such as Graves, Hashimoto’s, Type 1 Diabetes, Irritable Bowel Disease (IBD), Fibromyalgia, Lupus, and Crohn’s, to name a few.

Symptoms of Autoimmune Diseases

The indications of autoimmune disorders are varied and can consist of the following:

• Tiredness
• Pain in the joints
• Weight increase and challenges in weight loss
• Nervousness
• Feelings of sadness
• Decreased sexual desire
• Stomach discomfort
• Gastrointestinal problems
• Widespread inflammation

What Triggers Autoimmune Diseases?

The origins of autoimmune diseases are diverse and influenced by multiple factors, encompassing a range of genetic and environmental elements. Let’s delve into some of the key contributors to autoimmune diseases.

Genetic Susceptibility

Genetic factors can increase an individual’s vulnerability to autoimmune disorders, but they represent just a part of the overall picture. According to a saying in Functional Medicine: “genes load the gun, and the environment pulls the trigger,” which underscores the significance of environmental influences in the onset of autoimmune diseases (1).

Environmental Toxins

Environmental toxins, including heavy metals and harmful solvents like benzene from industrial facilities, may play a role in the development of autoimmune diseases. This is particularly true for individuals with a genetic predisposition, as these toxins can trigger epigenetic alterations that lead to immune system dysfunction and inflammatory reactions.

Stress

Stress refers to the body’s reaction to external pressures or demands that can lead to physical and mental strain. It is a common experience that can arise from various sources, including work, relationships, and personal challenges. Managing stress effectively is crucial for maintaining overall well-being and health.

Stress is a major factor that contributes to autoimmune diseases. Although genetic factors can increase the likelihood of developing an autoimmune disorder, it is often chronic stress that can act as a trigger. Recent studies emphasize the impact of psychological stress on autoimmune diseases. There is a notable prevalence of comorbidities between Post Traumatic Stress Disorder (PTSD) and autoimmune disorders, indicating that ongoing stress may lead to inflammation and changes in the HPA axis.

Gut Permeability

Intestinal permeability, commonly referred to as leaky gut, can lead to systemic inflammation, issues with nutrient absorption, and imbalances in the gut microbiome, factors that may be linked to autoimmune diseases.

Imbalances in the Gut Microbiome

The gut microbiome is essential for maintaining overall health, particularly in relation to the immune system. An imbalance in the gut microbiome, often caused by dysbiosis, can lead to disruptions in the levels of beneficial bacteria, ultimately affecting immune function. The makeup of the gut, which encompasses both the variety of bacteria present and the balance between helpful and harmful bacteria, can influence immune response.

Systemic Inflammation

Systemic inflammation, often referred to as silent inflammation, may arise from disruptions in the microbiome linked to a leaky gut and imbalances in the immune system. This type of inflammation can influence the body’s innate immune response and might be a factor in the onset of autoimmune diseases.

Discrepancy in the Immune System

A defining characteristic of autoimmune disorders is the body’s immune system mistakenly attacking its own healthy tissues, viewing them as foreign entities. This disruption within the immune system can lead to widespread inflammation throughout the body, which may play a role in the development of autoimmune conditions. Consequently, this triggers a series of responses characterized by self-sustaining inflammation, which can ultimately result in tissue harm. The precise cause of inflammation associated with autoimmunity stems from an abnormal or disrupted response from T-cells.

Hormonal Imbalances

Hormonal imbalances refer to the condition where there is an irregularity in the levels of hormones in the body. These fluctuations can lead to various physical and emotional symptoms, affecting overall health and well-being.

The functioning of the thyroid is crucial for maintaining overall well-being, which includes the health of the gut microbiome and immune system. Persistent stress and inflammation can lead to changes and disruptions in the HPA axis, which may result in hormonal imbalances that can adversely affect the thyroid and, consequently, immunity. Thyroid health has been linked to autoimmune diseases, as proper thyroid function is essential for the body to operate effectively and manage immune-related processes. The thyroid is particularly susceptible to autoimmune disorders.

Functional Medicine Laboratories for Identifying the Underlying Causes of Autoimmune Disorders

Several functional medicine laboratories are available to assess possible factors related to autoimmune diseases. Conducting tests is crucial as it provides the practitioner with a comprehensive view of the individual, similar to assembling various pieces of a puzzle, which aids in understanding the elements that contribute to autoimmunity.

Functional laboratories can include the following:

Detailed Stool Examination

The gut microbiome plays a crucial role in autoimmunity. This test offers an in-depth analysis of the gut microbiome’s bacterial diversity, composition, and the interaction of these bacteria with the host. Additionally, it identifies infectious parasites and pathogens.

Antinuclear Antibodies (ANA)

This examination evaluates the presence of antibodies that could suggest an autoimmune disorder. A positive result on the ANA test indicates the existence of autoantibodies, which would typically lead to additional laboratory testing for autoimmune diseases.

C-Reactive Protein (CRP)

This assessment measures inflammation levels. Elevated CRP levels can indicate inflammation and immune response, and can assist in identifying autoimmune conditions.

Complete Thyroid Assessment

Obtaining a thorough Thyroid Panel is crucial since various autoimmune disorders, including Hashimoto’s and Graves’ disease, affect the thyroid gland.

Food Allergies/Food Sensitivities

Evaluating food allergies or sensitivities is crucial, as they can reveal potential triggers for the body, particularly the gut and immune system. This is significant since approximately 80% of the immune system resides in the gut.

Reactions to gluten, dairy, or various other foods can lead to inflammatory symptoms, change the microbiome of the gut, and influence the immune response.

Exposure to Toxins

This assessment analyzes environmental toxic exposures through a straightforward urine sample, offering valuable information about potential contributors to autoimmune diseases. Environmental toxins can impact the thyroid, immune system, and gut function, all of which might be linked to autoimmunity.

Testing for Micronutrients

Nutritional deficiencies frequently manifest in individuals with autoimmune conditions because of malabsorption issues. As a result, it is crucial to ensure adequate levels of all essential vitamins and minerals that aid the body, particularly when managing autoimmunity.

Genetic Testing

This assessment offers valuable information regarding various aspects of health, particularly concerning inflammation, detoxification, and hormonal balance. The results enhance the understanding of how an individual’s bodily systems operate according to their distinct genetic profile, identifying potential vulnerabilities to certain conditions and highlighting areas that may require targeted assistance.

Infections

This assessment evaluates the antibody reactions to seven prevalent infections linked to autoimmune disorders of the nervous system.

Natural Options in Complementary and Integrative Medicine for Supporting Autoimmune Diseases

Functional Medicine provides various natural strategies for managing autoimmune diseases. After testing reveals possible factors contributing to the autoimmune condition, you can start to tackle these issues. Natural methods for supporting autoimmune diseases may encompass the following:

Focus on Gut Microbiome

Possible triggers can consist of sugar, wheat, processed foods, dairy, and gluten, as well as other food intolerances a person might experience. It may be beneficial to support gut health with amino acids like L-Glutamine.

The 5 R Protocol can be tailored to meet personal requirements. This dietary approach involves eliminating substances that disturb gut health, substituting them with digestive enzymes, hydrochloric acid (HCL), or bile that may be lacking, reintroducing probiotic-rich foods and nutrient-dense options, and ultimately, nourishing the gut lining with nutrients like glutamine.

Take Food Allergies and Sensitivities into Account

Food allergies and sensitivities can compromise the gut lining’s integrity, resulting in systemic inflammation, imbalances in the gut microbiome, and malabsorption, which may play a role in the development of autoimmune disorders.

Handle and Alleviate Stress

Elevated chronic stress can disrupt the balance of the immune system and alter the gut microbiome. It may lead to a decrease in stomach acid, influence the diversity and makeup of microbes, and contribute to increased intestinal permeability, commonly referred to as leaky gut. Additionally, ongoing stress can trigger inflammation and affect immune function.

Minimize Exposure to Toxins

Exposure to toxins in the environment can lead to oxidative stress, inflammation, and negatively impact the immune system. To minimize your contact with environmental pollutants, consider utilizing air and water filtration systems, opting for natural and fragrance-free cleaning products, and transitioning from plastic to glass containers for storage.

Take Infections into Account

Infections happen when the body is invaded by viruses, bacteria, or other microorganisms that begin to multiply. The immune system’s reaction to these infections typically leads to symptoms such as redness, inflammation, and fever. Furthermore, infections can sometimes activate autoimmune diseases, particularly in individuals who have a genetic vulnerability. If you think you may have an infection, it is crucial to seek medical help to eliminate this potential issue.

Diet for Autoimmune Disorders

Numerous studies indicate that diets rich in whole foods, anti-inflammatory properties, and plant-based ingredients could be beneficial for those with autoimmune diseases.

Studies indicate that dietary strategies incorporating elements of both a Mediterranean diet and a diet abundant in whole foods and unprocessed meats could be beneficial for autoimmune disorders.

Both dietary approaches prioritize the removal of ultra-processed foods and the inclusion of higher quantities of phytonutrients, which could play a role in regulating immune response and diminishing systemic inflammation. This includes an emphasis on fruits, vegetables, and locally sourced seafood.

The Autoimmune Protocol Diet (AIP) represents a functional medicine strategy aimed at managing autoimmune conditions. This diet is more limiting compared to the Mediterranean diet and other plant-based options. The primary goal of the AIP diet is to “reset” the gut and minimize inflammation by removing potential trigger foods, while simultaneously incorporating nutrient-rich foods to enhance bodily health.

The AIP diet promotes the consumption of various foods, including organic and locally sourced meats like seafood, venison, and poultry, as well as grass-fed organic beef. It also encourages the use of herbs and spices, non-dairy fermented products, bone broth, artichokes, parsnips, and green tea, alongside organic fruits and vegetables.

Herbal Remedies and Supplements That Could Aid in Recovery from Autoimmune Disorders

Numerous supplements can assist the body in handling autoimmune disorders. The primary goal of these supplements is to bolster the immune system and offer extensive support for the body’s health maintenance.

Vitamin D

Vitamin D plays a crucial role in immune system regulation and the modulation of inflammation, both of which are linked to autoimmune diseases. In a double-blind, randomized study involving 123 individuals diagnosed with autoimmune disorders, it was demonstrated that taking Vitamin D supplements over a period of 5 years led to a 22% reduction in the incidence of autoimmune diseases.

Omega 3 Fatty Acids

Omega-3 fatty acids might contribute to lowering inflammation and regulating immune responses. They have been suggested to assist with autoimmune disorders by decreasing inflammation levels. Research indicates that Omega-3 can enhance the quality of life for individuals with Multiple Sclerosis by decreasing the frequency of relapses and lowering inflammatory markers.

Zinc

Zinc is a trace mineral obtained from food sources, yet 15% of individuals in developed nations fail to reach the suggested intake levels. This mineral may aid in gut health, manage inflammation, and bolster the immune system. It plays a beneficial role in immunity and has been demonstrated to assist with autoimmune disorders such as rheumatoid arthritis and Crohn’s disease.

L-Glutamine

L-Glutamine is an amino acid that plays a crucial role in various bodily functions, including protein synthesis and immune system support. It serves as a vital energy source for cells, particularly during periods of stress or intense physical activity. Additionally, L-Glutamine aids in maintaining gut health and contributes to the overall well-being of the body.

Studies suggest that glutamine could play a role in maintaining the gut barrier, assisting in the regulation of intestinal permeability and diminishing inflammation, which has consequences for autoimmune disorders. It is regarded as one of the essential nutrients for promoting intestinal permeability, often referred to as leaky gut, since it serves as the primary energy source for intestinal cells.

Curcumin

Curcumin is a vibrant yellow compound derived from turmeric, known for its potential health benefits. It is widely recognized for its anti-inflammatory and antioxidant properties, making it a popular choice in both traditional and modern medicine. Research has indicated that curcumin may assist in managing various conditions, including arthritis, heart disease, and even certain types of cancer. Its bioavailability, however, can be an issue, often necessitating the use of additional substances to enhance absorption.

Curcumin, a component of the spice Turmeric, has been demonstrated to aid in maintaining intestinal permeability, also known as leaky gut, while also regulating inflammation and promoting a balanced gut microbiome. These effects could be beneficial in managing autoimmunity. In summary, research indicates that Curcumin supplementation can reduce inflammation in individuals with autoimmune disorders, and it has been noted that there are no harmful side effects associated with its use.

Probiotics

Probiotics might assist in repopulating the gastrointestinal tract with advantageous, health-promoting bacteria. This can aid in decreasing systemic inflammation, thus boosting immune response. Additionally, probiotics are capable of fortifying the intestinal barrier, potentially preventing the escape of toxins, harmful microorganisms, and undigested food remnants into the bloodstream, which could adversely impact the body’s overall health.

Utilizing Yoga, Chiropractic Care, and Acupuncture for Healing from Autoimmune Disorders

Due to the substantial role that stress plays in autoimmune diseases, complementary and integrative medicine (CIM) strategies could be highly beneficial in alleviating and managing symptoms.

Yoga: is a practice that connects the mind and body by purposefully transitioning into various poses. Research indicates that it can enhance vagal tone, reduce inflammation, and promote gut health and nervous system function, potentially offering advantages for individuals with autoimmune disorders. A 2019 randomized controlled trial involving 72 patients with Rheumatoid Arthritis (RA) revealed that after engaging in yoga for 8 weeks, participants experienced notable improvements in their symptoms, reflected in a decrease in multiple inflammatory markers.

Chiropractic: therapy focuses on correcting spinal misalignments. This type of Complementary and Integrative Medicine (CIM) could enhance autoimmunity by bolstering both nervous system and immune function while alleviating inflammation. Chiropractic care may alleviate pressure on the nervous system by enhancing the health and functionality of the cells, tissues, and organs it regulates. Furthermore, this treatment has been shown to activate the vagus nerve, promote relaxation, and release neurotrophins such as brain-derived neurotrophic factor (BDNF), which offers anti-inflammatory advantages and aids in maintaining nervous system equilibrium. These benefits may support individuals suffering from autoimmune conditions.

Acupuncture: This technique involves the insertion of fine needles into specific areas of the body to trigger positive physiological responses. It has been proposed to aid in the modulation of the immune system by alleviating stress and decreasing systemic inflammation, which is thought to be a contributing factor in autoimmune diseases. Consequently, acupuncture could serve as an effective treatment option for individuals suffering from these ailments.

Although the origins of autoimmune diseases are intricate and varied, there are numerous strategies that can aid in alleviating symptoms and enhancing overall well-being. By approaching autoimmune conditions through an evidence-based lens focused on root causes, healthcare providers can enable patients to collaborate with their body’s innate immune system to achieve natural symptom relief.

The content presented in this article serves educational purposes exclusively and should not be considered a replacement for professional medical guidance or treatment. This information is not meant to be used for diagnosing or addressing any medical issues or conditions without seeking advice from a physician. It is advisable to consult a healthcare professional before depending on any information provided in this article or on this website.

Laboratory Examinations Discussed in This Article

Stool

Blood Spot

• Bortun AC, et al. (2021). The Effect of Thyroid Autoimmune Disease on Sexual Function in Young Women. J Clin Med.
• Carri S, et al. (2022). Stoddard. A Systematic Review of the Links between Childhood Trauma and Multiple Sclerosis. Journal of Psychosomatic Research, Volume 160
• Francis Collins (2006). Director of the National Human Genome Research Institute, National Institutes of Health
• Carlet J. (2012). The Gut as the Core of Antibiotic Resistance. Antimicrob Resist Infect Control. 2012 Nov 27;1(1):39.
• Challa HJ et al. (2023). Paleolithic Diet. StatPearls Publishing;
• Cusick MF, Libbey JE, Fujinami RS. The Role of Molecular Mimicry in Autoimmune Disease. Clin Rev Allergy Immunol. 2012
• Gautam S, Tolahunase M, Kumar U, Dada R (2019). Effects of a Yoga-Based Mind-Body Intervention on Systemic Inflammatory Markers and Coexisting Depression in Patients with Active Rheumatoid Arthritis: A Randomized Controlled Study. Restor Neurol Neurosci.;37(1): 41-59.
• İnanç BB. (2020). A Different Perspective on Autoimmune Diseases and Acupuncture Treatment. J Pharmacopuncture, (4): 187-193.
• Kleinstern, G., Maurer, M.J., Liebow, M. et al. The Impact of Autoimmune Conditions on Lymphoma Prognosis. Blood Cancer Journal 8, 73 (2018).
• Liu Y et al. (2018). The Role of Probiotics in Autoimmune and Inflammatory Disorders. Nutrients.
• Mazzucca CB et al. (2021). Addressing the Connection between Autoimmune Diseases and Diet: A Good Start is Half the Battle. Nutrients.
• Pizzorno J. (2017). Reducing Toxin Exposure. Integr Med (Encinitas).
• Poles J, Karhu E, McGill M, McDaniel HR, Lewis JE. (2021). A Narrative Review of the Effects of Twenty-Four Nutrients and Phytonutrients on Immune Function and Inflammation. J Clin Transl Res.
• Tong, N et al. (2022). Measuring the Potency of Common Proinflammatory Cytokines to Assess Anxiety and Depression Risks in Psoriasis Patients. J Clin Lab Anal.
• Wessels I & Rink L (202). The Potential Therapeutic Benefits of Zinc and Vitamin D in Autoimmune Diseases. J Nutr Biochem.
• Wiertsema SP, et al (2021). The Interaction between the Gut Microbiome and the Immune System in Relation to Infectious Diseases Across the Lifespan and the Influence of Nutrition on Treatment Strategies. Nutrients.9, 13(3): 886.
• Yang M, Akbar U, Mohan C. (2019). The Role of Curcumin in Autoimmune and Rheumatic Diseases. Nutrients. 11(5)